The Autonomous Community of the Region of Murcia (Spanish: Comunidad Autónoma de la Región de Murcia) is one of Spain's seventeen autonomous communities. It is located in the southeast of the country, between Andalusia and Valencian Community, on the Mediterranean coast.

The autonomous community consists of a single province (region), unlike most autonomous communities, which have several provinces within the same region. Because of this, the autonomous community and the province are operated as one unit of government. The city of Murcia is the capital of the Region, and seat of government organs, except for the parliament (Regional Assembly), which is in Cartagena. The autonomous community and province is subdivided in municipalities.

The Region of Murcia is bordered by Andalucía (the provinces of Almería and Granada); Castilla-La Mancha (the province of Albacete), which was historically connected to Murcia until 1833; the Valencian Community (province of Alicante); and the Mediterranean Sea. The highest mountain is Revolcadores (2015 m).

The community measures 11,313 km² and has a population of 1.4 million, of whom one-third live in the capital.

The region is a major producer of fruits, vegetables, and flowers for Spain and the rest of Europe. Excellent wineries have developed near the towns of Bullas, Yecla, and Jumilla, as well as olive oil near Moratalla. Murcia is mainly a warm region which has made it very suitable for agriculture. However the precipitacion level is low and water supply is a hot subject today since, in addition to the traditional water demand for crops, there is now also a demand of water for the booming tourist developments which take advantage of the mild weather and beaches. Water is supplied by the Segura River or Río Segura and, ever since the 70's, by the Tajo transvasement, a major civil engineering which, under some environmental and sustaintibility restraints, brings water from the Tajo into the Segura.